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Preview	Issue Date	Title	Contributor(s)
	14-Jan-2019	Drug Design and Synthesis of First in Class PDZ1 Targeting NHERF1 Inhibitors as Anticancer Agents	Coluccia, Antonio; La Regina, Giuseppe; Naccarato, Valentina; Nalli, Marianna; Orlando, Viviana; Biagioni, Stefano; De Angelis, Maria Laura; Baiocchi, Marta; Gautier, Candice; Gianni, Stefano; Di Pastena, Fiorella; Di Magno, Laura; Canettieri, Gianluca; Coluccia, Addolorata Maria Luce; Silvestri, Romano
	22-May-2019	Discovery of Potent and Selective Covalent Protein Arginine Methyltransferase 5 (PRMT5) Inhibitors	Lin, Hong; Wang, Min; Zhang, Yang W.; Tong, Shuilong; Leal, Raul A.; Shetty, Rupa; Vaddi, Kris; Luengo, Juan I.
	15-Dec-2018	Synthesis and Anti-HIV Profile of a Novel Tetrahydroindazolylbenzamide Derivative Obtained by Oxazolone Chemistry	Scala, Angela; Piperno, Anna; Micale, Nicola; Christ, Frauke; Debyser, Zeger
	9-May-2019	Identification of a RIP1 Kinase Inhibitor Clinical Candidate (GSK3145095) for the Treatment of Pancreatic Cancer	Harris, Philip A.; Marinis, Jill M.; Lich, John D.; Berger, Scott B.; Chirala, Anirudh; Cox, Julie A.; Eidam, Patrick M.; Finger, Joshua N.; Gough, Peter J.; Jeong, Jae U.; Kang, James; Kasparcova, Viera; Leister, Lara K.; Mahajan, Mukesh K.; Miller, George; Nagilla, Rakesh; Ouellette, Michael T.; Reilly, Michael A.; Rendina, Alan R.; Rivera, Elizabeth J.; Sun, Helen H.; Thorpe, James H.; Totoritis, Rachel D.; Wang, Wei; Wu, Dongling; Zhang, Daohua; Bertin, John; Marquis, Robert W.
	24-Apr-2019	Correction to “Selective PPARδ Modulators Improve Mitochondrial Function: Potential Treatment for Duchenne Muscular Dystrophy (DMD)”	Lagu, Bharat; Kluge, Arthur F.; Tozzo, Effie; Fredenburg, Ross; Bell, Eric L.; Goddeeris, Matthew M.; Dwyer, Peter; Basinski, Andrew; Senaiar, Ramesh S.; Jaleel, Mahaboobi; Tiwari, Nirbhay Kumar; Panigrahi, Sunil K.; Krishnamurthy, Narasimha Rao; Takahashi, Taisuke; Patane, Michael A.
	13-Feb-2019	High-Resolution Crystal Structure of Endoplasmic Reticulum Aminopeptidase 1 with Bound Phosphinic Transition-State Analogue Inhibitor	Giastas, Petros; Neu, Margarete; Rowland, Paul; Stratikos, Efstratios
	13-Feb-2019	Behind the Mirror: Chirality Tunes the Reactivity and Cytotoxicity of Chloropiperidines as Potential Anticancer Agents	Carraro, Caterina; Francke, Alexander; Sosic, Alice; Kohl, Franziska; Helbing, Tim; De Franco, Michele; Fabris, Daniele; Göttlich, Richard; Gatto, Barbara
	7-Feb-2019	Atorvastatin (Lipitor) by MCR	Zarganes-Tzitzikas, Tryfon; Neochoritis, Constantinos G.; Dömling, Alexander
	20-Feb-2019	Correction to “Synthesis of 5-Thio-α-GalCer Analogues with Fluorinated Acyl Chain on Lipid Residue and Their Biological Evaluation”	He, Peng; Zhao, Chuanfang; Lu, Jiao; Zhang, Yang; Fang, Min; Du, Yuguo
	17-Feb-2019	Identification and Preclinical Evaluation of the Bicyclic Pyrimidine γ-Secretase Modulator BMS-932481	Boy, Kenneth M.; Guernon, Jason M.; Zuev, Dmitry S.; Xu, Li; Zhang, Yunhui; Shi, Jianliang; Marcin, Lawrence R.; Higgins, Mendi A.; Wu, Yong-Jin; Krishnananthan, Subramaniam; Li, Jianqing; Trehan, Ashok; Smith, Daniel; Toyn, Jeremy H.; Meredith, Jere E.; Burton, Catherine R.; Kimura, S. Roy; Zvyaga, Tatyana; Zhuo, Xiaoliang; Lentz, Kimberley A.; Grace, James E.; Denton, Rex; Morrison, John S.; Mathur, Arvind; Albright, Charles F.; Ahlijanian, Michael K.; Olson, Richard E.; Thompson, Lorin A.; Macor, John E.
	14-Feb-2019	Discovery of Soft-Drug Topical Tool Modulators of Sphingosine-1-phosphate Receptor 1 (S1PR1)	Bell, Mark; Foley, David; Naylor, Claire; Wood, Gavin; Robinson, Colin; Riley, Jennifer; Epemolu, Ola; Ellis, Lucy; Scullion, Paul; Shishikura, Yoko; Osuna-Cabello, Maria; Ferguson, Liam; Pinto, Erika; Fletcher, Daniel; Katz, Elad; McLean, W. H. Irwin; Wyatt, Paul; Read, Kevin D; Woodland, Andrew
	29-Nov-2018	Synthesis, Biological Evaluation and Structure–Activity Relationships of Diflapolin Analogues as Dual sEH/FLAP Inhibitors	Vieider, Lisa; Romp, Erik; Temml, Veronika; Fischer, Jana; Kretzer, Christian; Schoenthaler, Martin; Taha, Abdulla; Hernández-Olmos, Victor; Sturm, Sonja; Schuster, Daniela; Werz, Oliver; Garscha, Ulrike; Matuszczak, Barbara
	28-Feb-2019	Correction to “Light-Regulated NO Release as a Novel Strategy To Overcome Doxorubicin Multidrug Resistance”	Chegaev, Konstantin; Fraix, Aurore; Gazzano, Elena; Abd-Ellatef, Gamal Eldein F.; Blangetti, Marco; Rolando, Barbara; Conoci, Sabrina; Riganti, Chiara; Fruttero, Roberta; Gasco, Alberto; Sortino, Salvatore
	7-Nov-2018	Hybrid Inhibitors of Malarial Dihydrofolate Reductase with Dual Binding Modes That Can Forestall Resistance	Tarnchompoo, Bongkoch; Chitnumsub, Penchit; Jaruwat, Aritsara; Shaw, Philip J.; Vanichtanankul, Jarunee; Poen, Sinothai; Rattanajak, Roonglawan; Wongsombat, Chayaphat; Tonsomboon, Aunchalee; Decharuangsilp, Sasithorn; Anukunwithaya, Tosapol; Arwon, Uthai; Kamchonwongpaisan, Sumalee; Yuthavong, Yongyuth
	16-Nov-2018	Privileged Structures and Polypharmacology within and between Protein Families	Meyers, Joshua; Chessum, Nicola E. A.; Ali, Salyha; Mok, N. Yi; Wilding, Birgit; Pasqua, A. Elisa; Rowlands, Martin; Tucker, Michael J.; Evans, Lindsay E.; Rye, Carl S.; O’Fee, Lisa; Le Bihan, Yann-Vaï; Burke, Rosemary; Carter, Michael; Workman, Paul; Blagg, Julian; Brown, Nathan; van Montfort, Rob L. M.; Jones, Keith; Cheeseman, Matthew D.
	9-Nov-2018	Novel Fluorescence Competition Assay for Retinoic Acid Binding Proteins	Tomlinson, Charles W. E.; Chisholm, David R.; Valentine, Roy; Whiting, Andrew; Pohl, Ehmke
	18-Jun-2018	Discovery of Natural Product Derived Labdane Appended Triazoles as Potent Pancreatic Lipase Inhibitors	Jalaja, Renjitha; Leela, Shyni G.; Valmiki, Praveen K.; Salfeena, Chettiyan Thodi F.; Ashitha, Kizhakkan T.; Krishna Rao, Venkata Rao D.; Nair, Mangalam S.; Gopalan, Raghu K.; Somappa, Sasidhar B.
	28-Jun-2018	Nicotinamide Phosphoribosyltransferase Inhibitor as a Novel Payload for Antibody–Drug Conjugates	Karpov, Alexei S.; Abrams, Tinya; Clark, Suzanna; Raikar, Ankita; D’Alessio, Joseph A.; Dillon, Michael P.; Gesner, Thomas G.; Jones, Darryl; Lacaud, Marion; Mallet, William; Martyniuk, Piotr; Meredith, Erik; Mohseni, Morvarid; Nieto-Oberhuber, Cristina M.; Palacios, Daniel; Perruccio, Francesca; Piizzi, Grazia; Zurini, Mauro; Bialucha, Carl Uli
	7-May-2018	Plasmin-Binding Tripeptide-Decorated Liposomes Loading Pyrazolo[3,4-d]pyrimidines for Targeting Hepatocellular Carcinoma	Calandro, Pierpaolo; Iovenitti, Giulia; Zamperini, Claudio; Candita, Francesca; Dreassi, Elena; Chiariello, Mario; Angelucci, Adriano; Schenone, Silvia; Botta, Maurizio; Mancini, Arianna
	18-Sep-2018	Optimization of Phenyl Indole Inhibitors of the AAA+ ATPase p97	LaPorte, Matthew G.; Burnett, James C.; Colombo, Raffaele; Bulfer, Stacie L.; Alverez, Celeste; Chou, Tsui-Fen; Neitz, R. Jeffrey; Green, Neal; Moore, William J.; Yue, Zhizhou; Li, Shan; Arkin, Michelle R.; Wipf, Peter; Huryn, Donna M.